Stanislas Lyonnet is currently Professor of Genetics at the University Paris V, geneticist at the Hospital “Necker-Enfants malades” and Director of the Institut Imagine.
Dr Lyonnet studied Paediatrics and Genetics at the Pierre-and-Marie-Curie University. He obtained his Doctorate in Medicine, specializing in Pediatrics, in 1989. He obtained a Master of Science degree from the Institut Cochin and a PhD in Genetics from Necker in 1992. In 1995 he was appointed Full Professor in the Genetic Department of the Paris Descartes Medical School. He was also responsible of the Rare Disease Research Program of the French national agency for research (ANR) and was awarded with the City of Paris Jean Hamburger Prize in 2006 and in 2009 with the INSERM Research Award.
Stanislas Lyonnet has been head of the board of the European Society of Human Genetics and member of its scientific program committee. He is a section editor of the European Journal of Human Genetics, and is on the editorial boards of Human Molecular Genetics and Clinical Dysmorphology. He is also director of the École Normale Supérieure Scientific Council.
His research focuses on identifying genes or non-coding genomic alterations responsible for congenital malformations, particularly in tissues derived from the neural crest and ciliopathies. His group is interested in the development of the enteric nervous systems and Hirschsprung disease, a model for complex oligogenic and sex-dependent inheritance.
In collaboration with many reference centers for rare diseases on the Necker Hospital campus they have also developed research projects on craniofacial (especially mandibulofacial dysostosis), syndromic deafness and cardiac malformations through Next Generation Sequencing, in vitro and in vivo analysis in zebrafish and mice.