Dr Amritpal Mudher is Associate Professor in Neurosciences within Biological Sciences at the University of Southampton. She is the Principal Investigator of the Neurodegenerative diseases group, aiming at investigating the mechanisms that underpin tau-mediated dysfunction and degeneration in tauopathies such as Alzheimer’s disease and fronto-temporal dementia.
The key current research projects of her group include:
- Understanding the mechanisms underpinning tau mediated neuronal dysfunction and degeneration in tauopathies such as Alzheimer’s disease.
- Identifiying disease-modifying tau-centred therapeutic targets.
- Unravelling mechanisms that underpin cross talk between tau and Abeta peptide in Alzheimer’s disease.
- Understanding the mechanisms by which aging processes contribute to neurodegenerative diseases like Alzheimer’s disease.
- Using the unique structural attributes of misfolded proteins to develop label-free biomarkers.
Amriptal obtained her PhD in Neuroscience in 1998, at the Merton College of the University of Oxford in the UK. She was studying the regulation of phosphorylation of neuronal cytoskeletal elements at this time. Then she started her investigation on Alzheimer’s Disease as a post-doctoral researcher at he Institute of Psychiatry of the University of London.
In 2001, she was awarded a Fellowship from the Alzheimer Society to pursue her work at the Institute of Psychiatry in London, by modelling tauopathies in Drosophila. In 2004 Dr Mudher got a position as a Lecturer in Neurosciences at the University of Southampton, in the UK. And since 2014, she is an Associate Professor at this University. She is also the Principal Investigator of the Neurodegenerative Diseases group, part of the Biomedical Sciences Research Group of the University of Southampton.